Hcar1 | hydrocarboxylic acid receptor 1
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton Renal/urinary system
14 No significant impact
3 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased effector memory T-helper cell number | 1 supporting dataset | Hcar1em1(IMPC)Ccpcz | homozygote | Early adult | 1.3x10-6 | ||
| hyperactivity | 1 supporting dataset | Hcar1em1(IMPC)Ccpcz | homozygote | Early adult | 1.08x10-5 | ||
| abnormal vertebral arch morphology | 1 supporting dataset | Hcar1em1(IMPC)Ccpcz | homozygote | Early adult | 8.38x10-5 | ||
| abnormal kidney morphology | 1 supporting dataset | Hcar1em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal pelvic girdle bone morphology | 1 supporting dataset | Hcar1em1(IMPC)Ccpcz | homozygote | Early adult | 4.32x10-8 | ||
| abnormal tibia morphology | 1 supporting dataset | Hcar1em1(IMPC)Ccpcz | homozygote | Early adult | 5.86x10-7 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Hcar1em1(IMPC)Ccpcz | homozygote | Early adult | 2.57x10-5 | ||
| vertebral transformation | 1 supporting dataset | Hcar1em1(IMPC)Ccpcz | homozygote | Early adult | 7.74x10-6 | ||
| decreased anxiety-related response | 1 supporting dataset | Hcar1em1(IMPC)Ccpcz | homozygote | Early adult | 1.35x10-5 |
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Human diseases caused by Hcar1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Hcar1.
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