Hcar1 | hydrocarboxylic acid receptor 1

GeneMGI:2441671Synonyms: Gpr81

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton Renal/urinary system

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased effector memory T-helper cell number1 supporting datasetHcar1em1(IMPC)CcpczhomozygoteEarly adult1.3x10-6 
hyperactivity1 supporting datasetHcar1em1(IMPC)CcpczhomozygoteEarly adult1.08x10-5 
abnormal vertebral arch morphology1 supporting datasetHcar1em1(IMPC)CcpczhomozygoteEarly adult8.38x10-5 
abnormal kidney morphology1 supporting datasetHcar1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
abnormal pelvic girdle bone morphology1 supporting datasetHcar1em1(IMPC)CcpczhomozygoteEarly adult4.32x10-8 
abnormal tibia morphology1 supporting datasetHcar1em1(IMPC)CcpczhomozygoteEarly adult5.86x10-7 
increased circulating alkaline phosphatase level1 supporting datasetHcar1em1(IMPC)CcpczhomozygoteEarly adult2.57x10-5 
vertebral transformation1 supporting datasetHcar1em1(IMPC)CcpczhomozygoteEarly adult7.74x10-6 
decreased anxiety-related response1 supporting datasetHcar1em1(IMPC)CcpczhomozygoteEarly adult1.35x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Hcar1em1(IMPC)CcpczIndelmouse
Hcar1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell

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