Brms1 | breast cancer metastasis-suppressor 1
GeneMGI:2388804
Physiological systems
17 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Behavior/neurological Mortality/aging
14 No significant impact
7 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| increased startle reflex | 1 supporting dataset | Brms1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 7.37x10-6 | ||
| increased circulating chloride level | 1 supporting dataset | Brms1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 2.54x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Brms1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased circulating sodium level | 1 supporting dataset | Brms1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.25x10-7 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/1) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 50% (1/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 50% (1/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 50% (1/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | n/a | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Brms1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Brms1.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Brms1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Brms1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Brms1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Brms1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Brms1tm3(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |