Igsf11 | immunoglobulin superfamily, member 11
Physiological systems
17 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Behavior/neurological
14 No significant impact
7 Not tested
Data collections
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:51Adult tissues
47Embryo tissues
| limb grasping | 1 supporting dataset | Igsf11tm1b(KOMP)Wtsi | homozygote | Late adult | 6.81x10-8 | ||
| impaired righting response | 1 supporting dataset | Igsf11tm1b(KOMP)Wtsi | homozygote | Late adult | 2.36x10-7 | ||
| hyperactivity | 1 supporting dataset | Igsf11tm1b(KOMP)Wtsi | homozygote | Late adult | 5.63x10-5 | ||
| male infertility | 1 supporting dataset | Igsf11tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| increased fasting circulating glucose level | 1 supporting dataset | Igsf11tm1b(KOMP)Wtsi | homozygote | Early adult | 8.34x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Igsf11 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Igsf11.
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| Igsf11tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Igsf11tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Igsf11tm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |
| Igsf11tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Igsf11tm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Igsf11tm3a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Igsf11tm3e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Igsf11tm42518(L1L2_Pgk_PM) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |