Katnal1 | katanin p60 subunit A-like 1
GeneMGI:2387638
Physiological systems
20 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Immune system Integument Growth/size/body region Vision/eye Hematopoietic system Cardiovascular system Mortality/aging Renal/urinary system
12 No significant impact
4 Not tested
Data collections
Gene metrics:14Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Katnal1em1(IMPC)Tcp | heterozygote | Early adult | 1.09x10-5 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Katnal1em1(IMPC)Tcp | heterozygote | Early adult | 3.74x10-5 | ||
| pallor | 1 supporting dataset | Katnal1em1(IMPC)Tcp | homozygote | E18.5 | N/A * | ||
| decreased mean corpuscular volume | 1 supporting dataset | Katnal1em1(IMPC)Tcp | heterozygote | Early adult | 3.83x10-10 | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Katnal1em1(IMPC)Tcp | heterozygote | Early adult | 3.56x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Katnal1em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| cataract | 1 supporting dataset | Katnal1em1(IMPC)Tcp | heterozygote | Early adult | 6.69x10-7 | ||
| preweaning lethality, incomplete penetrance | 2 supporting datasets | Katnal1em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| enlarged urinary bladder | 1 supporting dataset | Katnal1em1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| enlarged lymph nodes | 1 supporting dataset | Katnal1em1(IMPC)Tcp | heterozygote | Early adult | N/A * |
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Human diseases caused by Katnal1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Katnal1.
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| Katnal1em1(IMPC)Tcp | Exon Deletion | | mouse |
| Katnal1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Katnal1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |