Tardbp | TAR DNA binding protein
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Behavior/neurological Skeleton Mortality/aging
14 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
3Associated diseases
Expression examined in:46Adult tissues
21Embryo tissues
| decreased bone mineral content | 2 supporting datasets | Tardbptm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.94x10-5 | ||
| decreased mean platelet volume | 1 supporting dataset | Tardbptm1b(EUCOMM)Wtsi | heterozygote | Early adult | 6.95x10-29 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Tardbptm1b(EUCOMM)Wtsi | homozygote | E9.5 | N/A * | ||
| decreased blood urea nitrogen level | 1 supporting dataset | Tardbptm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.69x10-5 | ||
| decreased bone mineral density | 1 supporting dataset | Tardbptm1b(EUCOMM)Wtsi | heterozygote | Early adult | 7.08x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Tardbptm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal startle reflex | 1 supporting dataset | Tardbptm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.17x10-9 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Tardbp mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tardbp.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Tardbpem1H | Indel | | mouse |
| Tardbptm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Tardbptm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Tardbptm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Tardbptm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |