Tardbp | TAR DNA binding protein
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Behavior/neurological Skeleton Mortality/aging
14 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
3Associated diseases
Expression examined in:46Adult tissues
21Embryo tissues
| decreased bone mineral content | 2 supporting datasets | Tardbptm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.94x10-5 | ||
| decreased mean platelet volume | 1 supporting dataset | Tardbptm1b(EUCOMM)Wtsi | heterozygote | Early adult | 6.95x10-29 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Tardbptm1b(EUCOMM)Wtsi | homozygote | E9.5 | N/A * | ||
| decreased blood urea nitrogen level | 1 supporting dataset | Tardbptm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.69x10-5 | ||
| decreased bone mineral density | 1 supporting dataset | Tardbptm1b(EUCOMM)Wtsi | heterozygote | Early adult | 7.08x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Tardbptm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal startle reflex | 1 supporting dataset | Tardbptm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.17x10-9 |
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External links
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| Tardbpem1H | Indel | | mouse |
| Tardbptm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector es cell |
| Tardbptm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector es cell mouse |
| Tardbptm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Tardbptm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | es cell |