Wac | WW domain containing adaptor with coiled-coil

GeneMGI:2387357Synonyms: A230035H12Rik, Wwp4, +1 more

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Skeleton Craniofacial Mortality/aging

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Wac^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased circulating amylase level	1 supporting dataset	Wac^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	1.07x10^-9
fusion of vertebral arches	1 supporting dataset	Wac^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	9.73x10^-5
decreased circulating triglyceride level	1 supporting dataset	Wac^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	3.46x10^-5
increased mean platelet volume	1 supporting dataset	Wac^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	8.45x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Wac^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	1.2x10^-5
decreased eosinophil cell number	2 supporting datasets	Wac^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*
increased Ly6C low monocyte number	2 supporting datasets	Wac^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*
increased monocyte cell number	2 supporting datasets	Wac^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*
abnormal cranium morphology	1 supporting dataset	Wac^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	4.43x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Wac.

Associated images

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Histopathology

There is no histopathology data found for Wac.

IMPC related publications

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External links

No external links available for Wac.

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*Wac^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Wac^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Wac^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Wac^{tm2b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Wac^{tm2c(EUCOMM)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse

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