Dusp7 | dual specificity phosphatase 7

GeneMGI:2387100Synonyms: MKP-X, PYST2

Physiological systems

15 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Pigmentation Integument Behavior/neurological Cardiovascular system

9 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal coat/hair pigmentation	5 supporting datasets	Dusp7^{tm1(KOMP)Wtsi}	homozygote	Early adult	2.95x10^-7
dilated heart left ventricle	1 supporting dataset	Dusp7^{tm1(KOMP)Wtsi}	homozygote	Early adult	1.95x10^-5
female infertility	1 supporting dataset	Dusp7^{tm1(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased circulating HDL cholesterol level	1 supporting dataset	Dusp7^{tm1(KOMP)Wtsi}	homozygote	Early adult	7.14x10^-9
male infertility	1 supporting dataset	Dusp7^{tm1(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased circulating cholesterol level	1 supporting dataset	Dusp7^{tm1(KOMP)Wtsi}	homozygote	Early adult	2.27x10^-6
increased startle reflex	1 supporting dataset	Dusp7^{tm1(KOMP)Wtsi}	homozygote	Early adult	8.12x10^-6
abnormal cholesterol homeostasis	1 supporting dataset	Dusp7^{tm1(KOMP)Wtsi}	homozygote	Early adult	5.98x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dusp7.

Associated images

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Histopathology

There is no histopathology data found for Dusp7.

IMPC related publications

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External links

No external links available for Dusp7.

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*Dusp7^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell mouse

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