Gipc3 | GIPC PDZ domain containing family, member 3
Physiological systems
17 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Hearing/vestibular/ear Vision/eye Nervous system Hematopoietic system Cardiovascular system
10 No significant impact
7 Not tested
Data collections
Gene metrics:9Significant phenotypes
2Associated diseases
Expression examined in:51Adult tissues
50Embryo tissues
| abnormal auditory brainstem response | 5 supporting datasets | Gipc3tm1b(KOMP)Wtsi | homozygote | Early adult | 3.91x10-14 | ||
| abnormal epididymis morphology | 1 supporting dataset | Gipc3tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| thrombocytopenia | 1 supporting dataset | Gipc3tm1b(KOMP)Wtsi | homozygote | Early adult | 7.9x10-5 | ||
| abnormal spinal cord morphology | 1 supporting dataset | Gipc3tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| microphthalmia | 1 supporting dataset | Gipc3tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| increased mean corpuscular volume | 1 supporting dataset | Gipc3tm1b(KOMP)Wtsi | homozygote | Early adult | 7.96x10-5 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Gipc3tm1b(KOMP)Wtsi | homozygote | Early adult | 3.02x10-10 | ||
| shortened PR interval | 1 supporting dataset | Gipc3tm1b(KOMP)Wtsi | homozygote | Early adult | 7.71x10-5 | ||
| decreased circulating chloride level | 1 supporting dataset | Gipc3tm1b(KOMP)Wtsi | homozygote | Early adult | 9.79x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
Human diseases caused by Gipc3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Gipc3.
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| Gipc3tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Gipc3tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Gipc3tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |