Gipc3 | GIPC PDZ domain containing family, member 3

GeneMGI:2387006Synonyms: Rgs19ip3, Ahl5, +1 more

Physiological systems

17 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Hearing/vestibular/ear Vision/eye Nervous system Hematopoietic system Cardiovascular system

10 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

2Associated diseases

Expression examined in:51Adult tissues

50Embryo tissues

Phenotypes

Phy. System:



abnormal auditory brainstem response	5 supporting datasets	Gipc3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.91x10^-14
abnormal epididymis morphology	1 supporting dataset	Gipc3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
thrombocytopenia	1 supporting dataset	Gipc3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.9x10^-5
abnormal spinal cord morphology	1 supporting dataset	Gipc3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
microphthalmia	1 supporting dataset	Gipc3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased mean corpuscular volume	1 supporting dataset	Gipc3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.96x10^-5
increased mean corpuscular hemoglobin	1 supporting dataset	Gipc3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.02x10^-10
shortened PR interval	1 supporting dataset	Gipc3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.71x10^-5
decreased circulating chloride level	1 supporting dataset	Gipc3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.79x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gipc3.

Associated images

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Histopathology

There is no histopathology data found for Gipc3.

IMPC related publications

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External links

No external links available for Gipc3.

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*Gipc3^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Gipc3^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Gipc3^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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