Dlat | dihydrolipoamide S-acetyltransferase
Physiological systems
20 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Nervous system Behavior/neurological Mortality/aging
17 No significant impact
4 Not tested
Data collections
Gene metrics:3Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased prepulse inhibition | 6 supporting datasets | Dlatem1(IMPC)J | heterozygote | Early adult | 2.31x10-172 | ||
| decreased exploration in new environment | 1 supporting dataset | Dlatem1(IMPC)J | heterozygote | Early adult | 2.12x10-7 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Dlatem1(IMPC)J | homozygote | Early adult | N/A * |
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Human diseases caused by Dlat mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Dlat.
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| Dlatem1(IMPC)J | Exon Deletion | | mouse |
| Dlattm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Dlattm39548(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |