Tpcn2 | two pore segment channel 2
Physiological systems
22 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Hematopoietic system Behavior/neurological
18 No significant impact
2 Not tested
Data collections
Gene metrics:5Significant phenotypes
1Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| increased eosinophil cell number | 1 supporting dataset | Tpcn2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.97x10-5 | ||
| abnormal vocalization | 1 supporting dataset | Tpcn2Gt(YHD437)Byg | homozygote | Early adult | 5.1x10-6 | ||
| increased circulating triglyceride level | 1 supporting dataset | Tpcn2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.36x10-5 | ||
| abnormal behavior | 2 supporting datasets | Tpcn2Gt(YHD437)Byg | homozygote | Early adult | 4.81x10-6 | ||
| decreased circulating sodium level | 1 supporting dataset | Tpcn2Gt(YHD437)Byg | homozygote | Early adult | 3.08x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (8/8) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (4/4) | 0.19% (1/533) |
| bone | heterozygote | n/a | 100% (8/8) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (8/8) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (8/8) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/8) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (8/8) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (8/8) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 28.57% (2/7) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/8) | 1.67% (7/419) |
Human diseases caused by Tpcn2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tpcn2.
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| Tpcn2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Tpcn2tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Tpcn2tm1c(EUCOMM)Hmgu | Wild type floxed exon (post-Flp) | | mouse |
| Tpcn2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |