Tpcn2 | two pore segment channel 2

GeneMGI:2385297Synonyms: D830047E22Rik

Physiological systems

22 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Behavior/neurological

18 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

1Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Allele:

Phy. System:



increased eosinophil cell number	1 supporting dataset	Tpcn2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.97x10^-5
abnormal vocalization	1 supporting dataset	Tpcn2^{Gt(YHD437)Byg}	homozygote	Early adult	5.1x10^-6
increased circulating triglyceride level	1 supporting dataset	Tpcn2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.36x10^-5
abnormal behavior	2 supporting datasets	Tpcn2^{Gt(YHD437)Byg}	homozygote	Early adult	4.81x10^-6
decreased circulating sodium level	1 supporting dataset	Tpcn2^{Gt(YHD437)Byg}	homozygote	Early adult	3.08x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tpcn2.

Associated images

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Histopathology

There is no histopathology data found for Tpcn2.

IMPC related publications

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External links

No external links available for Tpcn2.

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*Tpcn2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Tpcn2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Tpcn2^{tm1c(EUCOMM)Hmgu}*	Wild type floxed exon (post-Flp)	‌	mouse
*Tpcn2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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