Cnot3 | CCR4-NOT transcription complex, subunit 3
Physiological systems
17 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Liver/biliary system Behavior/neurological Skeleton Renal/urinary system
11 No significant impact
7 Not tested
Data collections
Gene metrics:15Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased thigmotaxis | 2 supporting datasets | Cnot3em1(IMPC)Rbrc | heterozygote | Early adult | 1.01x10-6 | ||
| decreased locomotor activity | 5 supporting datasets | Cnot3em1(IMPC)Rbrc | heterozygote | Early adult | 1.26x10-6 | ||
| abnormal male genitalia morphology | 2 supporting datasets | Cnot3em1(IMPC)Rbrc | heterozygote | Early adult | 4.13x10-8 | ||
| abnormal liver morphology | 2 supporting datasets | Cnot3em1(IMPC)Rbrc | heterozygote | Early adult | N/A * | ||
| hyperactivity | 1 supporting dataset | Cnot3em1(IMPC)Rbrc | heterozygote | Early adult | 8.53x10-6 | ||
| hydrometra | 1 supporting dataset | Cnot3em1(IMPC)Rbrc | heterozygote | Early adult | N/A * | ||
| abnormal behavior | 1 supporting dataset | Cnot3em1(IMPC)Rbrc | heterozygote | Early adult | 1.01x10-6 | ||
| abnormal uterus morphology | 1 supporting dataset | Cnot3em1(IMPC)Rbrc | heterozygote | Early adult | N/A * | ||
| increased circulating bilirubin level | 1 supporting dataset | Cnot3em1(IMPC)Rbrc | heterozygote | Early adult | 9.67x10-6 | ||
| absent external male genitalia | 1 supporting dataset | Cnot3em1(IMPC)Rbrc | heterozygote | Early adult | 4.13x10-8 |
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Human diseases caused by Cnot3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cnot3.
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| Cnot3em1(IMPC)Rbrc | Indel | | mouse |
| Cnot3tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Cnot3tm380175(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Cnot3tm47215(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |