Cnot3 | CCR4-NOT transcription complex, subunit 3

GeneMGI:2385261Synonyms: A930039N10Rik

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Liver/biliary system Behavior/neurological Skeleton Renal/urinary system

11 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased thigmotaxis	2 supporting datasets	Cnot3^{em1(IMPC)Rbrc}	heterozygote	Early adult	1.01x10^-6
decreased locomotor activity	5 supporting datasets	Cnot3^{em1(IMPC)Rbrc}	heterozygote	Early adult	1.26x10^-6
abnormal male genitalia morphology	2 supporting datasets	Cnot3^{em1(IMPC)Rbrc}	heterozygote	Early adult	4.13x10^-8
abnormal liver morphology	2 supporting datasets	Cnot3^{em1(IMPC)Rbrc}	heterozygote	Early adult	N/A ^*
hyperactivity	1 supporting dataset	Cnot3^{em1(IMPC)Rbrc}	heterozygote	Early adult	8.53x10^-6
hydrometra	1 supporting dataset	Cnot3^{em1(IMPC)Rbrc}	heterozygote	Early adult	N/A ^*
abnormal behavior	1 supporting dataset	Cnot3^{em1(IMPC)Rbrc}	heterozygote	Early adult	1.01x10^-6
abnormal uterus morphology	1 supporting dataset	Cnot3^{em1(IMPC)Rbrc}	heterozygote	Early adult	N/A ^*
increased circulating bilirubin level	1 supporting dataset	Cnot3^{em1(IMPC)Rbrc}	heterozygote	Early adult	9.67x10^-6
absent external male genitalia	1 supporting dataset	Cnot3^{em1(IMPC)Rbrc}	heterozygote	Early adult	4.13x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cnot3.

Associated images

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Histopathology

There is no histopathology data found for Cnot3.

IMPC related publications

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External links

No external links available for Cnot3.

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*Cnot3^{em1(IMPC)Rbrc}*	Indel	‌	mouse
*Cnot3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Cnot3^{tm380175(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Cnot3^{tm47215(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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