Clcc1 | chloride channel CLIC-like 1
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Embryo Growth/size/body region Hematopoietic system Mortality/aging
15 No significant impact
5 Not tested
Data collections
Gene metrics:6Significant phenotypes
1Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| abnormal embryo turning | 1 supporting dataset | Clcc1tm1b(KOMP)Mbp | homozygote | E9.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Clcc1tm1b(KOMP)Mbp | homozygote | E9.5 | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Clcc1tm1b(KOMP)Mbp | homozygote | E12.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Clcc1tm1b(KOMP)Mbp | homozygote | E9.5 | N/A * | ||
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Clcc1tm1b(KOMP)Mbp | heterozygote | Early adult | 2.83x10-11 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Clcc1tm1b(KOMP)Mbp | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Clcc1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Clcc1.
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| Clcc1tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Clcc1tm1b(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | mouse |