Rabgap1 | RAB GTPase activating protein 1

GeneMGI:2385139Synonyms: Gapcena

Physiological systems

22 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Renal/urinary system

9 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:23Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



decreased locomotor activity	2 supporting datasets	Rabgap1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.3x10^-6
persistence of hyaloid vascular system	1 supporting dataset	Rabgap1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.1x10^-5
decreased circulating total protein level	1 supporting dataset	Rabgap1^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	3.89x10^-7
improved glucose tolerance	2 supporting datasets	Rabgap1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.35x10^-7
enlarged urinary bladder	1 supporting dataset	Rabgap1^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
hydrocephaly	1 supporting dataset	Rabgap1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal retina morphology	1 supporting dataset	Rabgap1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.8x10^-5
decreased grip strength	1 supporting dataset	Rabgap1^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	3.71x10^-5
decreased total retina thickness	1 supporting dataset	Rabgap1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.99x10^-6
decreased prepulse inhibition	2 supporting datasets	Rabgap1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.86x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rabgap1.

Associated images

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Histopathology

There is no histopathology data found for Rabgap1.

IMPC related publications

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External links

No external links available for Rabgap1.

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*Rabgap1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Rabgap1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Rabgap1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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