Rabgap1 | RAB GTPase activating protein 1
Physiological systems
22 / 24 physiological systems tested
13 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Renal/urinary system
9 No significant impact
2 Not tested
Data collections
Gene metrics:23Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased locomotor activity | 2 supporting datasets | Rabgap1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.3x10-6 | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Rabgap1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.1x10-5 | ||
| decreased circulating total protein level | 1 supporting dataset | Rabgap1tm1b(EUCOMM)Hmgu | homozygote | Late adult | 3.89x10-7 | ||
| improved glucose tolerance | 2 supporting datasets | Rabgap1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.35x10-7 | ||
| enlarged urinary bladder | 1 supporting dataset | Rabgap1tm1b(EUCOMM)Hmgu | homozygote | Late adult | N/A * | ||
| hydrocephaly | 1 supporting dataset | Rabgap1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal retina morphology | 1 supporting dataset | Rabgap1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.8x10-5 | ||
| decreased grip strength | 1 supporting dataset | Rabgap1tm1b(EUCOMM)Hmgu | homozygote | Late adult | 3.71x10-5 | ||
| decreased total retina thickness | 1 supporting dataset | Rabgap1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.99x10-6 | ||
| decreased prepulse inhibition | 2 supporting datasets | Rabgap1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.86x10-6 |
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Human diseases caused by Rabgap1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Rabgap1.
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| Rabgap1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Rabgap1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Rabgap1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |