Spns2 | SPNS lysolipid transporter 2, sphingosine-1-phosphate

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Pigmentation Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:28Significant phenotypes

1Associated diseases

Expression examined in:90Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



decreased leukocyte cell number	1 supporting dataset	Spns2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.08x10^-39
abnormal pupil morphology	1 supporting dataset	Spns2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.75x10^-5
cornea vascularization	1 supporting dataset	Spns2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	4.21x10^-21
excessive tearing	1 supporting dataset	Spns2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.58x10^-6
abnormal eyelid aperture	1 supporting dataset	Spns2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	7.24x10^-6
increased thermal nociceptive threshold	1 supporting dataset	Spns2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	6.97x10^-5
absent pinna reflex	1 supporting dataset	Spns2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.54x10^-30
cornea opacity	1 supporting dataset	Spns2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.34x10^-21
absent pinna reflex	1 supporting dataset	Spns2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.77x10^-11
decreased leukocyte cell number	1 supporting dataset	Spns2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.89x10^-17

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Spns2.

Associated images

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Histopathology

There is no histopathology data found for Spns2.

IMPC related publications

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External links

No external links available for Spns2.

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*Spns2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Spns2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Spns2^{tm1c(KOMP)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Spns2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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