Spns2 | SPNS lysolipid transporter 2, sphingosine-1-phosphate
GeneMGI:2384936
Physiological systems
20 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Pigmentation Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system
12 No significant impact
4 Not tested
Data collections
Gene metrics:28Significant phenotypes
1Associated diseases
Expression examined in:90Adult tissues
0Embryo tissues
| decreased leukocyte cell number | 1 supporting dataset | Spns2tm1b(KOMP)Wtsi | homozygote | Early adult | 4.08x10-39 | ||
| abnormal pupil morphology | 1 supporting dataset | Spns2tm1a(KOMP)Wtsi | homozygote | Early adult | 1.75x10-5 | ||
| cornea vascularization | 1 supporting dataset | Spns2tm1a(KOMP)Wtsi | homozygote | Early adult | 4.21x10-21 | ||
| excessive tearing | 1 supporting dataset | Spns2tm1a(KOMP)Wtsi | homozygote | Early adult | 5.58x10-6 | ||
| abnormal eyelid aperture | 1 supporting dataset | Spns2tm1a(KOMP)Wtsi | homozygote | Early adult | 7.24x10-6 | ||
| increased thermal nociceptive threshold | 1 supporting dataset | Spns2tm1a(KOMP)Wtsi | homozygote | Early adult | 6.97x10-5 | ||
| absent pinna reflex | 1 supporting dataset | Spns2tm1a(KOMP)Wtsi | homozygote | Early adult | 5.54x10-30 | ||
| cornea opacity | 1 supporting dataset | Spns2tm1a(KOMP)Wtsi | homozygote | Early adult | 1.34x10-21 | ||
| absent pinna reflex | 1 supporting dataset | Spns2tm1b(KOMP)Wtsi | homozygote | Early adult | 9.77x10-11 | ||
| decreased leukocyte cell number | 1 supporting dataset | Spns2tm1a(KOMP)Wtsi | homozygote | Early adult | 1.89x10-17 |
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| adrenal gland | homozygote | n/a | 0% (0/1) | 0.7% (4/570) |
| adrenal gland | heterozygote | n/a | 0% (0/11) | 0.7% (4/570) |
| aorta | homozygote | n/a | n/a | 0.19% (1/533) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | homozygote | n/a | 0% (0/1) | 0% (0/173) |
| blood vessel | heterozygote | n/a | 0% (0/11) | 0% (0/173) |
| bone | homozygote | n/a | 100% (1/1) | 0% (0/394) |
| bone | heterozygote | n/a | 100% (11/11) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (11/11) | 0.86% (5/579) |
| brain | homozygote | n/a | 100% (1/1) | 0.86% (5/579) |
Human diseases caused by Spns2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Spns2.
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| Spns2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Spns2tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Spns2tm1c(KOMP)Wtsi | Wild type floxed exon (post-Flp) | | mouse |
| Spns2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |