Cep290 | centrosomal protein 290

GeneMGI:2384917Synonyms: b2b1454Clo, Nphp6, +2 more

Physiological systems

22 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Embryo Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging Craniofacial Cardiovascular system

15 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

10Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal head shape	1 supporting dataset	Cep290^em1(IMPC)Mbp	homozygote	E18.5	N/A ^*
abnormal blood vessel morphology	1 supporting dataset	Cep290^em1(IMPC)Mbp	homozygote	E18.5	N/A ^*
no spontaneous movement	1 supporting dataset	Cep290^em1(IMPC)Mbp	heterozygote	E18.5	N/A ^*
decreased mean corpuscular hemoglobin	1 supporting dataset	Cep290^em1(IMPC)Mbp	heterozygote	Early adult	6.48x10^-5
abnormal facial morphology	1 supporting dataset	Cep290^em1(IMPC)Mbp	homozygote	E18.5	N/A ^*
hemorrhage	1 supporting dataset	Cep290^em1(IMPC)Mbp	homozygote	E18.5	N/A ^*
no spontaneous movement	1 supporting dataset	Cep290^em1(IMPC)Mbp	homozygote	E18.5	N/A ^*
decreased mean corpuscular hemoglobin concentration	1 supporting dataset	Cep290^em1(IMPC)Mbp	heterozygote	Early adult	7.02x10^-5
preweaning lethality, incomplete penetrance	3 supporting datasets	Cep290^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal placenta morphology	1 supporting dataset	Cep290^em1(IMPC)Mbp	homozygote	E18.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cep290.

Associated images

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Histopathology

There is no histopathology data found for Cep290.

IMPC related publications

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External links

No external links available for Cep290.

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*Cep290^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Cep290^em1H*	Point Mutation	‌	mouse
*Cep290^{tm387964(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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