Alg1 | ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase

GeneMGI:2384774Synonyms: HMT1, HMAT1

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Pigmentation Integument Hematopoietic system Mortality/aging

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal coat/hair pigmentation	3 supporting datasets	Alg1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	8.8x10^-7
abnormal cholesterol homeostasis	1 supporting dataset	Alg1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.37x10^-6
increased basophil cell number	2 supporting datasets	Alg1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	5.44x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Alg1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased eosinophil cell number	2 supporting datasets	Alg1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	4.81x10^-10
increased lymphocyte cell number	1 supporting dataset	Alg1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.41x10^-5
increased leukocyte cell number	1 supporting dataset	Alg1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	9.16x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Alg1.

Associated images

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Histopathology

There is no histopathology data found for Alg1.

IMPC related publications

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External links

No external links available for Alg1.

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*Alg1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Alg1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Alg1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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