Hectd1 | HECT domain E3 ubiquitin protein ligase 1

GeneMGI:2384768Synonyms: b2b327Clo, A630086P08Rik, +1 more

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Pigmentation Integument Hematopoietic system

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased basophil cell number	2 supporting datasets	Hectd1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.21x10^-40
increased eosinophil cell number	2 supporting datasets	Hectd1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	8.38x10^-21
decreased circulating alkaline phosphatase level	1 supporting dataset	Hectd1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.75x10^-5
increased circulating calcium level	1 supporting dataset	Hectd1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.15x10^-10
abnormal coat/hair pigmentation	1 supporting dataset	Hectd1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	8.76x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hectd1.

Associated images

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Histopathology

There is no histopathology data found for Hectd1.

IMPC related publications

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External links

No external links available for Hectd1.

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*Hectd1^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Hectd1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Hectd1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Hectd1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

My Genes