Aars1 | alanyl-tRNA synthetase 1

GeneMGI:2384560Synonyms: Aars

Physiological systems

16 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Adipose tissue Growth/size/body region Limbs/digits/tail Mortality/aging

12 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

7Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	3 supporting datasets	Aars1^em1(IMPC)Bay	homozygote	Early adult	N/A ^*
increased lean body mass	1 supporting dataset	Aars1^em1(IMPC)Bay	heterozygote	Early adult	1.54x10^-5
abnormal tail length	1 supporting dataset	Aars1^em1(IMPC)Bay	heterozygote	Early adult	4.82x10^-7
abnormal head morphology	1 supporting dataset	Aars1^em1(IMPC)Bay	heterozygote	Early adult	4.03x10^-5
decreased total body fat amount	2 supporting datasets	Aars1^em1(IMPC)Bay	heterozygote	Early adult	4.7x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Aars1.

Associated images

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Histopathology

There is no histopathology data found for Aars1.

IMPC related publications

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External links

No external links available for Aars1.

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*Aars1^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Aars1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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