Ell2 | elongation factor for RNA polymerase II 2
GeneMGI:2183438
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Behavior/neurological
15 No significant impact
6 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| increased grip strength | 4 supporting datasets | Ell2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 8.24x10-8 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Ell2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.52x10-7 | ||
| abnormal retina morphology | 1 supporting dataset | Ell2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.34x10-5 | ||
| cataract | 1 supporting dataset | Ell2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.21x10-9 | ||
| abnormal lens morphology | 1 supporting dataset | Ell2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.3x10-9 | ||
| cataract | 1 supporting dataset | Ell2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.3x10-9 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Ell2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.4x10-5 | ||
| abnormal lens morphology | 1 supporting dataset | Ell2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.21x10-9 | ||
| decreased circulating serum albumin level | 1 supporting dataset | Ell2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 4.52x10-5 |
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| adrenal gland | heterozygote | n/a | 50% (2/4) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (4/4) | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 50% (2/4) | 0% (0/173) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 50% (2/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 50% (2/4) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 50% (2/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 50% (2/4) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 50% (2/4) | 0.41% (2/491) |
Human diseases caused by Ell2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ell2.
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| Ell2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ell2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ell2tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ell2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Ell2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |