Ell2 | elongation factor for RNA polymerase II 2

GeneMGI:2183438

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Behavior/neurological

15 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



increased grip strength	4 supporting datasets	Ell2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.24x10^-8
increased circulating alkaline phosphatase level	1 supporting dataset	Ell2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.52x10^-7
abnormal retina morphology	1 supporting dataset	Ell2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.34x10^-5
cataract	1 supporting dataset	Ell2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.21x10^-9
abnormal lens morphology	1 supporting dataset	Ell2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.3x10^-9
cataract	1 supporting dataset	Ell2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.3x10^-9
increased circulating alkaline phosphatase level	1 supporting dataset	Ell2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.4x10^-5
abnormal lens morphology	1 supporting dataset	Ell2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.21x10^-9
decreased circulating serum albumin level	1 supporting dataset	Ell2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.52x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ell2.

Associated images

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Histopathology

There is no histopathology data found for Ell2.

IMPC related publications

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External links

No external links available for Ell2.

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*Ell2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Ell2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ell2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ell2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Ell2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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