Rspo1 | R-spondin 1
Physiological systems
22 / 24 physiological systems tested
13 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Adipose tissue Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Skeleton Renal/urinary system
9 No significant impact
2 Not tested
Data collections
Gene metrics:18Significant phenotypes
2Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| abnormal testis morphology | 1 supporting dataset | Rspo1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| abnormal retina outer nuclear layer morphology | 2 supporting datasets | Rspo1tm2b(KOMP)Wtsi | homozygote | Early adult | 2.11x10-6 | ||
| increased bone mineral content | 1 supporting dataset | Rspo1tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.36x10-5 | ||
| decreased total retina thickness | 2 supporting datasets | Rspo1tm2b(KOMP)Wtsi | homozygote | Early adult | 2.73x10-7 | ||
| abnormal eye anterior chamber depth | 2 supporting datasets | Rspo1tm2b(KOMP)Wtsi | homozygote | Early adult | 2x10-9 | ||
| abnormal kidney morphology | 1 supporting dataset | Rspo1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased grip strength | 1 supporting dataset | Rspo1tm1.1(KOMP)Vlcg | homozygote | Early adult | 9.23x10-6 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Rspo1tm2b(KOMP)Wtsi | homozygote | Early adult | 3.44x10-5 | ||
| small testis | 1 supporting dataset | Rspo1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| abnormal vitreous body morphology | 2 supporting datasets | Rspo1tm2b(KOMP)Wtsi | homozygote | Early adult | 3.88x10-10 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by Rspo1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Rspo1.
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| Rspo1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Rspo1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Rspo1tm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Rspo1tm2b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |