Rspo1 | R-spondin 1

GeneMGI:2183426Synonyms: Rspondin, R-spondin

Physiological systems

22 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Adipose tissue Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Skeleton Renal/urinary system

9 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



abnormal testis morphology	1 supporting dataset	Rspo1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal retina outer nuclear layer morphology	2 supporting datasets	Rspo1^{tm2b(KOMP)Wtsi}	homozygote	Early adult	2.11x10^-6
increased bone mineral content	1 supporting dataset	Rspo1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.36x10^-5
decreased total retina thickness	2 supporting datasets	Rspo1^{tm2b(KOMP)Wtsi}	homozygote	Early adult	2.73x10^-7
abnormal eye anterior chamber depth	2 supporting datasets	Rspo1^{tm2b(KOMP)Wtsi}	homozygote	Early adult	2x10^-9
abnormal kidney morphology	1 supporting dataset	Rspo1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased grip strength	1 supporting dataset	Rspo1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	9.23x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Rspo1^{tm2b(KOMP)Wtsi}	homozygote	Early adult	3.44x10^-5
small testis	1 supporting dataset	Rspo1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal vitreous body morphology	2 supporting datasets	Rspo1^{tm2b(KOMP)Wtsi}	homozygote	Early adult	3.88x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rspo1.

Associated images

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Histopathology

There is no histopathology data found for Rspo1.

IMPC related publications

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External links

No external links available for Rspo1.

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*Rspo1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Rspo1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Rspo1^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Rspo1^{tm2b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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