Ash1l | ASH1 like histone lysine methyltransferase

GeneMGI:2183158Synonyms: E430018P19Rik, chromatin remodeling factor, +2 more

Physiological systems

18 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system

9 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal coat appearance	1 supporting dataset	Ash1l^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	1.69x10^-6
increased fasting circulating glucose level	1 supporting dataset	Ash1l^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	8.35x10^-5
increased heart weight	1 supporting dataset	Ash1l^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	9.53x10^-10
increased eosinophil cell number	2 supporting datasets	Ash1l^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	6.46x10^-18
increased basophil cell number	2 supporting datasets	Ash1l^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	1.34x10^-20
impaired pupillary reflex	1 supporting dataset	Ash1l^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	7.37x10^-12
preweaning lethality, complete penetrance	1 supporting dataset	Ash1l^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased grip strength	1 supporting dataset	Ash1l^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	4.51x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Ash1l.

Associated images

Loading...

Histopathology

There is no histopathology data found for Ash1l.

IMPC related publications

Loading...

External links

No external links available for Ash1l.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Ash1l^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ash1l^{tm2b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

My Genes