Grhl2 | grainyhead like transcription factor 2

GeneMGI:2182543Synonyms: BOM, clft3, +3 more

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Embryo Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Cardiovascular system Mortality/aging Craniofacial

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:21Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal neural tube closure	1 supporting dataset	Grhl2^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
abnormal hindbrain development	1 supporting dataset	Grhl2^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
exencephaly	1 supporting dataset	Grhl2^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal optic vesicle formation	1 supporting dataset	Grhl2^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
abnormal head shape	1 supporting dataset	Grhl2^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal heart morphology	1 supporting dataset	Grhl2^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
abnormal limb morphology	1 supporting dataset	Grhl2^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
syndactyly	1 supporting dataset	Grhl2^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal placenta morphology	1 supporting dataset	Grhl2^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Grhl2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Grhl2.

Associated images

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Histopathology

There is no histopathology data found for Grhl2.

IMPC related publications

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External links

No external links available for Grhl2.

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*Grhl2^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Grhl2^{tm50612(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
	KO first allele (reporter-tagged insertion with conditional potential)	‌	ES Cell mouse

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