Hps6 | HPS6, biogenesis of lysosomal organelles complex 2 subunit 3

GeneMGI:2181763Synonyms: ru, BLOC-2, +3 more

Physiological systems

18 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Immune system Pigmentation Integument Endocrine/exocrine gland Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

8 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



mydriasis	1 supporting dataset	Hps6^em1(IMPC)Tcp	homozygote	Early adult	3.75x10^-11
abnormal coat/hair pigmentation	3 supporting datasets	Hps6^em1(IMPC)Tcp	homozygote	Early adult	2x10^-19
abnormal retina vasculature morphology	1 supporting dataset	Hps6^em1(IMPC)Tcp	homozygote	Early adult	3.45x10^-7
hyperactivity	1 supporting dataset	Hps6^em1(IMPC)Tcp	homozygote	Early adult	4.98x10^-5
small thymus	1 supporting dataset	Hps6^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
decreased body length	1 supporting dataset	Hps6^em1(IMPC)Tcp	homozygote	Early adult	1.18x10^-6
small spleen	1 supporting dataset	Hps6^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal retina blood vessel morphology	1 supporting dataset	Hps6^em1(IMPC)Tcp	homozygote	Early adult	3.86x10^-7
abnormal skin morphology	2 supporting datasets	Hps6^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Hps6^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hps6.

Associated images

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Histopathology

There is no histopathology data found for Hps6.

IMPC related publications

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External links

No external links available for Hps6.

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*Hps6^em1(IMPC)Tcp*	Intra-exon deletion	‌	mouse
*Hps6^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Hps6^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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