Tox | thymocyte selection-associated high mobility group box
Physiological systems
21 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Nervous system Hearing/vestibular/ear Liver/biliary system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system
11 No significant impact
3 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| decreased prepulse inhibition | 5 supporting datasets | Toxtm1b(KOMP)Wtsi | homozygote | Early adult | 2.1x10-12 | ||
| abnormal auditory brainstem response | 4 supporting datasets | Toxtm1b(KOMP)Wtsi | homozygote | Early adult | 5.22x10-5 | ||
| decreased liver weight | 1 supporting dataset | Toxtm1b(KOMP)Wtsi | homozygote | Early adult | 7.65x10-6 | ||
| abnormal startle reflex | 1 supporting dataset | Toxtm1b(KOMP)Wtsi | homozygote | Early adult | 5.73x10-13 | ||
| decreased circulating cholesterol level | 1 supporting dataset | Toxtm1b(KOMP)Wtsi | homozygote | Early adult | 1.4x10-5 | ||
| decreased bone mineral density | 1 supporting dataset | Toxtm1b(KOMP)Wtsi | homozygote | Early adult | 1.51x10-11 | ||
| decreased bone mineral content | 1 supporting dataset | Toxtm1b(KOMP)Wtsi | homozygote | Early adult | 8.98x10-8 | ||
| prolonged RR interval | 1 supporting dataset | Toxtm1b(KOMP)Wtsi | homozygote | Early adult | 8.87x10-5 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Toxtm1b(KOMP)Wtsi | homozygote | Early adult | 1.84x10-5 | ||
| increased spleen weight | 1 supporting dataset | Toxtm1b(KOMP)Wtsi | homozygote | Early adult | 6.59x10-11 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/1) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by Tox mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tox.
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| Toxtm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Toxtm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Toxtm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |