Tox | thymocyte selection-associated high mobility group box

GeneMGI:2181659Synonyms: 1700007F02Rik

Physiological systems

21 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Nervous system Hearing/vestibular/ear Liver/biliary system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

11 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased prepulse inhibition	5 supporting datasets	Tox^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.1x10^-12
abnormal auditory brainstem response	4 supporting datasets	Tox^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.22x10^-5
decreased liver weight	1 supporting dataset	Tox^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.65x10^-6
abnormal startle reflex	1 supporting dataset	Tox^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.73x10^-13
decreased circulating cholesterol level	1 supporting dataset	Tox^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.4x10^-5
decreased bone mineral density	1 supporting dataset	Tox^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.51x10^-11
decreased bone mineral content	1 supporting dataset	Tox^{tm1b(KOMP)Wtsi}	homozygote	Early adult	8.98x10^-8
prolonged RR interval	1 supporting dataset	Tox^{tm1b(KOMP)Wtsi}	homozygote	Early adult	8.87x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Tox^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.84x10^-5
increased spleen weight	1 supporting dataset	Tox^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.59x10^-11

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Tox.

Associated images

Loading...

Histopathology

There is no histopathology data found for Tox.

IMPC related publications

Loading...

External links

No external links available for Tox.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Tox^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Tox^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Tox^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

My Genes