Lgi4 | leucine-rich repeat LGI family, member 4
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Growth/size/body region Vision/eye Behavior/neurological Mortality/aging Craniofacial
15 No significant impact
4 Not tested
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:73Adult tissues
76Embryo tissues
| microphthalmia | 1 supporting dataset | Lgi4tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Lgi4tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| abnormal facial morphology | 1 supporting dataset | Lgi4tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| decreased thigmotaxis | 2 supporting datasets | Lgi4tm1.1(KOMP)Vlcg | heterozygote | Early adult | 3.29x10-8 | ||
| hyperactivity | 1 supporting dataset | Lgi4tm1.1(KOMP)Vlcg | heterozygote | Early adult | 4.47x10-6 | ||
| abnormal craniofacial morphology | 1 supporting dataset | Lgi4tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| abnormal behavior | 1 supporting dataset | Lgi4tm1.1(KOMP)Vlcg | heterozygote | Early adult | 3.31x10-8 |
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External links
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| Lgi4tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Lgi4tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Lgi4tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |