Naxe | NAD(P)HX epimerase
Physiological systems
17 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Immune system Growth/size/body region Hematopoietic system Behavior/neurological
13 No significant impact
7 Not tested
Data collections
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
| increased red blood cell distribution width | 1 supporting dataset | Naxetm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.61x10-8 | ||
| decreased startle reflex | 1 supporting dataset | Naxetm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.72x10-5 | ||
| decreased hemoglobin content | 1 supporting dataset | Naxetm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.52x10-6 | ||
| increased spleen weight | 1 supporting dataset | Naxetm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.93x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Naxe mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Naxe.
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| Naxetm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Naxetm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Naxetm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |