Dicer1 | dicer 1, ribonuclease type III

GeneMGI:2177178Synonyms: D12Ertd7e, 1110006F08Rik, +1 more

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Mortality/aging

12 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

11Associated diseases

Expression examined in:46Adult tissues

21Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased neutrophil cell number	1 supporting dataset	Dicer1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.98x10^-5
decreased lean body mass	2 supporting datasets	Dicer1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	7.54x10^-5
decreased red blood cell distribution width	1 supporting dataset	Dicer1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.13x10^-7
increased circulating alkaline phosphatase level	1 supporting dataset	Dicer1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.85x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Dicer1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Dicer1^{tm1b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
decreased spleen weight	1 supporting dataset	Dicer1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	8.28x10^-5
decreased grip strength	1 supporting dataset	Dicer1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.29x10^-5
embryonic lethality prior to organogenesis	1 supporting dataset	Dicer1^{tm1b(EUCOMM)Wtsi}	homozygote	E9.5	N/A ^*
absent spleen	1 supporting dataset	Dicer1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dicer1.

Associated images

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Histopathology

There is no histopathology data found for Dicer1.

IMPC related publications

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External links

No external links available for Dicer1.

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*Dicer1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Dicer1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Dicer1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Dicer1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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