Idh3b | isocitrate dehydrogenase 3 (NAD+) beta

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Reproductive system Vision/eye Behavior/neurological

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

male infertility1 supporting datasetIdh3bem1(IMPC)JhomozygoteEarly adultN/A * 
hyperactivity5 supporting datasetsIdh3bem1(IMPC)JhomozygoteEarly adult7.16x10-7 
impaired righting response1 supporting datasetIdh3bem1(IMPC)JhomozygoteLate adult3.5x10-5 
abnormal retina morphology1 supporting datasetIdh3bem1(IMPC)JhomozygoteLate adult7.98x10-6 
limb grasping1 supporting datasetIdh3bem1(IMPC)JhomozygoteLate adult1.2x10-5 
increased vertical activity1 supporting datasetIdh3bem1(IMPC)JhomozygoteEarly adult3.73x10-8 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Idh3bem1(IMPC)JExon Deletionmouse
Idh3btm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell

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