Med16 | mediator complex subunit 16
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Embryo Growth/size/body region Liver/biliary system Mortality/aging
15 No significant impact
5 Not tested
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
29Embryo tissues
| abnormal placenta size | 1 supporting dataset | Med16tm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Med16tm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| pale yolk sac | 1 supporting dataset | Med16tm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| preweaning lethality, complete penetrance | 2 supporting datasets | Med16tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Med16tm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| abnormal placenta size | 1 supporting dataset | Med16tm1b(KOMP)Wtsi | heterozygote | E12.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Med16tm1b(KOMP)Wtsi | heterozygote | E12.5 | N/A * | ||
| pale liver | 1 supporting dataset | Med16tm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Med16tm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * |
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Human diseases caused by Med16 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Med16.
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| Med16tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Med16tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Med16tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |