Dppa1 | developmental pluripotency associated 1

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Embryo Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Mortality/aging

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:51Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Dppa1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Dppa1^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
increased respiratory quotient	1 supporting dataset	Dppa1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.16x10^-6
abnormal pericardium morphology	1 supporting dataset	Dppa1^{tm1b(KOMP)Wtsi}	heterozygote	E9.5	N/A ^*
increased food intake	1 supporting dataset	Dppa1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.41x10^-5
abnormal embryo turning	1 supporting dataset	Dppa1^{tm1b(KOMP)Wtsi}	heterozygote	E9.5	N/A ^*
increased lean body mass	1 supporting dataset	Dppa1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.94x10^-6
increased bone mineral density	1 supporting dataset	Dppa1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	4.34x10^-8
abnormal spleen morphology	1 supporting dataset	Dppa1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dppa1.

Associated images

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Histopathology

There is no histopathology data found for Dppa1.

IMPC related publications

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External links

No external links available for Dppa1.

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*Dppa1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Dppa1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Dppa1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Dppa1^{tm37733(L1L2_st1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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