Synpo2 | synaptopodin 2

GeneMGI:2153070Synonyms: 2310068J10Rik, 9530006G20Rik, +3 more

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Immune system Hematopoietic system Cardiovascular system Mortality/aging

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased leukocyte cell number	1 supporting dataset	Synpo2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.05x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Synpo2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased hematocrit	1 supporting dataset	Synpo2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4.3x10^-5
prolonged PR interval	1 supporting dataset	Synpo2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.97x10^-5
decreased hemoglobin content	1 supporting dataset	Synpo2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.71x10^-6
increased neutrophil cell number	1 supporting dataset	Synpo2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4.19x10^-9
decreased lymphocyte cell number	2 supporting datasets	Synpo2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.34x10^-9
decreased erythrocyte cell number	1 supporting dataset	Synpo2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.84x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Synpo2.

Associated images

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Histopathology

There is no histopathology data found for Synpo2.

IMPC related publications

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External links

No external links available for Synpo2.

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*Synpo2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Synpo2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Synpo2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Synpo2^{tm44538(L1L2_gt2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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