Parvb | parvin, beta

GeneMGI:2153063Synonyms: D15Gsk1, affixin

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Behavior/neurological Skeleton

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased circulating serum albumin level	1 supporting dataset	Parvb^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.28x10^-5
increased startle reflex	5 supporting datasets	Parvb^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.26x10^-6
decreased circulating total protein level	1 supporting dataset	Parvb^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.28x10^-6
increased circulating alanine transaminase level	1 supporting dataset	Parvb^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.32x10^-6
increased granulocyte number	1 supporting dataset	Parvb^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.47x10^-9
decreased NK cell number	1 supporting dataset	Parvb^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.1x10^-6
decreased circulating glucose level	1 supporting dataset	Parvb^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.12x10^-6
decreased hemoglobin content	1 supporting dataset	Parvb^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.47x10^-5
increased bone mineral content	1 supporting dataset	Parvb^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.64x10^-6
increased bone mineral density	1 supporting dataset	Parvb^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.82x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Parvb.

Associated images

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Histopathology

There is no histopathology data found for Parvb.

IMPC related publications

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External links

No external links available for Parvb.

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*Parvb^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Parvb^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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