Asb7 | ankyrin repeat and SOCS box-containing 7
Physiological systems
21 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Integument Growth/size/body region Muscle Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system
10 No significant impact
3 Not tested
Data collections
Gene metrics:20Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased locomotor activity | 1 supporting dataset | Asb7em1(IMPC)Ccpcz | homozygote | Early adult | 5.26x10-5 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Asb7em1(IMPC)Ccpcz | homozygote | Early adult | 1.74x10-7 | ||
| abnormal eye morphology | 2 supporting datasets | Asb7em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 2 supporting datasets | Asb7em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased cardiac muscle contractility | 2 supporting datasets | Asb7em1(IMPC)Ccpcz | homozygote | Early adult | 4.38x10-5 | ||
| decreased grip strength | 1 supporting dataset | Asb7em1(IMPC)Ccpcz | homozygote | Early adult | 1.68x10-5 | ||
| decreased exploration in new environment | 1 supporting dataset | Asb7em1(IMPC)Ccpcz | homozygote | Early adult | 3.81x10-10 | ||
| enlarged heart | 1 supporting dataset | Asb7em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| decreased CD8-positive, alpha-beta T cell number | 1 supporting dataset | Asb7em1(IMPC)Ccpcz | homozygote | Early adult | 1.04x10-5 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Asb7em1(IMPC)Ccpcz | homozygote | Early adult | 1.13x10-15 |
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Human diseases caused by Asb7 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Asb7.
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| Asb7em1(IMPC)Ccpcz | Intra-exon deletion | | mouse |
| Asb7tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Asb7tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |