Gsk3a | glycogen synthase kinase 3 alpha

GeneMGI:2152453Synonyms: 2700086H06Rik

Physiological systems

22 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system Craniofacial

15 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



abnormal gait	1 supporting dataset	Gsk3a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.74x10^-7
abnormal gait	1 supporting dataset	Gsk3a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.86x10^-12
decreased body weight	1 supporting dataset	Gsk3a^{not yet available}	homozygote	Early adult	2.57x10^-7
decreased body weight	4 supporting datasets	Gsk3a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.76x10^-6
decreased circulating glucose level	1 supporting dataset	Gsk3a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.21x10^-5
improved glucose tolerance	1 supporting dataset	Gsk3a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.18x10^-5
increased total body fat amount	1 supporting dataset	Gsk3a^{not yet available}	homozygote	Early adult	9.33x10^-5
decreased exploration in new environment	1 supporting dataset	Gsk3a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.05x10^-6
prolonged QRS complex duration	1 supporting dataset	Gsk3a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.93x10^-5
decreased mean platelet volume	1 supporting dataset	Gsk3a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.96x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gsk3a.

Associated images

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Histopathology

There is no histopathology data found for Gsk3a.

IMPC related publications

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External links

No external links available for Gsk3a.

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*Gsk3a^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Gsk3a^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Gsk3a^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Gsk3a^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Gsk3a^{tm40413(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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