Gopc | golgi associated PDZ and coiled-coil motif containing
Physiological systems
20 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Digestive/alimentary Mortality/aging
17 No significant impact
4 Not tested
Gene metrics:5Significant phenotypes
1Associated diseases
Expression examined in:73Adult tissues
29Embryo tissues
| abnormal cecum morphology | 2 supporting datasets | Gopctm1e.1(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
| enlarged cecum | 2 supporting datasets | Gopctm1e.1(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Gopctm1e.1(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating phosphate level | 1 supporting dataset | Gopctm1e.1(EUCOMM)Wtsi | heterozygote | Early adult | 3.06x10-8 | ||
| decreased circulating calcium level | 1 supporting dataset | Gopctm1e.1(EUCOMM)Wtsi | heterozygote | Early adult | 8.01x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by Gopc mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Gopc.
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| Gopctm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Gopctm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell mouse |
| Gopctm1e.1(EUCOMM)Wtsi | Promoter excision from Targeted, non-conditional allele | | mouse |