Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Slc38a5 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Hyperinsulinemic Hypoglycemia, Familial, 2 | Nesidioblastosis, Pancreatic islet-cell hyperplasia | OMIM:601820 | |
Pancreas, Annular | Annular pancreas | OMIM:167750 | |
Annular Pancreas | Annular pancreas | ORPHA:675 | |
Duodenal Atresia | Annular pancreas, Abnormality of the pancreas | ORPHA:1203 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Slc38a5.
There are 3 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Impairment of serine transport across the blood-brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction. | Proceedings of the National Academy of Sciences of the United States of America (October 2023) | Slc38a5tm1(KOMP)Vlcg | 37812701 |
Amino acid transporter SLC38A5 regulates developmental and pathological retinal angiogenesis. | eLife (December 2022) | Slc38a5tm1(KOMP)Vlcg | PMC9714971 |
Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice. | Cell metabolism (June 2017) | Slc38a5tm1(KOMP)Vlcg | 28591637 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Slc38a5tm40643(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Slc38a5tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | Mice, ES Cells |
Slc38a5tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Get highlights of the most important data releases, news and events, delivered straight to your email inbox
Subscribe to newsletter