Uqcc3 | ubiquinol-cytochrome c reductase complex assembly factor 3
Physiological systems
14 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Embryo Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Hearing/vestibular/ear Cardiovascular system Mortality/aging Craniofacial
5 No significant impact
10 Not tested
Data collections
Gene metrics:20Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal otic vesicle morphology | 1 supporting dataset | Uqcc3em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal hindbrain development | 1 supporting dataset | Uqcc3em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Uqcc3em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| abnormal visceral yolk sac morphology | 1 supporting dataset | Uqcc3em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal tail bud morphology | 1 supporting dataset | Uqcc3em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal pericardium morphology | 1 supporting dataset | Uqcc3em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Uqcc3em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal pharyngeal arch morphology | 1 supporting dataset | Uqcc3em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal heart looping | 1 supporting dataset | Uqcc3em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Uqcc3em1(IMPC)Bay | homozygote | E9.5 | N/A * |
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Human diseases caused by Uqcc3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Uqcc3.
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| Uqcc3em1(IMPC)Bay | Whole-gene deletion | | mouse |
| Uqcc3tm1(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Uqcc3tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |