Mpig6b | megakaryocyte and platelet inhibitory receptor G6b

GeneMGI:2146995Synonyms: AU023871, G6b

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Respiratory system Hematopoietic system

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal spleen morphology	2 supporting datasets	Mpig6b^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
enlarged spleen	2 supporting datasets	Mpig6b^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
decreased bronchoconstrictive response	2 supporting datasets	Mpig6b^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6x10^-8
small testis	1 supporting dataset	Mpig6b^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased spleen weight	1 supporting dataset	Mpig6b^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.22x10^-10
increased pulmonary respiratory rate	1 supporting dataset	Mpig6b^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	7.75x10^-5
abnormal testis morphology	1 supporting dataset	Mpig6b^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased mean platelet volume	1 supporting dataset	Mpig6b^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.6x10^-7
decreased circulating phosphate level	1 supporting dataset	Mpig6b^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	4.94x10^-7
thrombocytopenia	1 supporting dataset	Mpig6b^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.07x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mpig6b.

Associated images

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Histopathology

There is no histopathology data found for Mpig6b.

IMPC related publications

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External links

No external links available for Mpig6b.

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*Mpig6b^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Mpig6b^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Mpig6b^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Mpig6b^{tm210463(L1L2_Pgk_P)}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector

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