Topors | topoisomerase I binding, arginine/serine-rich

Physiological systems

17 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Adipose tissue Growth/size/body region Hearing/vestibular/ear Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

7 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:19Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased bone mineral content	1 supporting dataset	Topors^em1(IMPC)J	homozygote	Early adult	7.33x10^-15
increased total body fat amount	2 supporting datasets	Topors^em1(IMPC)J	homozygote	Early adult	0
hyperactivity	7 supporting datasets	Topors^em1(IMPC)J	homozygote	Early adult	3.62x10^-18
decreased lean body mass	2 supporting datasets	Topors^em1(IMPC)J	homozygote	Early adult	0
increased circulating glucose level	1 supporting dataset	Topors^em1(IMPC)J	homozygote	Early adult	1.67x10^-7
prolonged RR interval	1 supporting dataset	Topors^em1(IMPC)J	homozygote	Early adult	2.29x10^-7
increased circulating alkaline phosphatase level	1 supporting dataset	Topors^em1(IMPC)J	homozygote	Early adult	1.85x10^-10
prolonged QT interval	1 supporting dataset	Topors^em1(IMPC)J	homozygote	Early adult	2.76x10^-6
increased vertical activity	1 supporting dataset	Topors^em1(IMPC)J	homozygote	Early adult	6.74x10^-5
female infertility	1 supporting dataset	Topors^em1(IMPC)J	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Topors.

Associated images

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Histopathology

There is no histopathology data found for Topors.

IMPC related publications

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External links

No external links available for Topors.

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*Topors^em1(IMPC)J*	Exon Deletion	‌	mouse

My Genes