Dip2b | disco interacting protein 2 homolog B

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Hematopoietic system Skeleton Cardiovascular system

14 No significant impact

5 Not tested

Data collections

Viability data
Body weight measurements
Embryo imaging data
Gene metrics:6Significant phenotypes
1Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

increased bone mineral density1 supporting datasetDip2btm1a(EUCOMM)WtsiheterozygoteEarly adult2.61x10-5 
increased heart weight1 supporting datasetDip2btm1a(EUCOMM)WtsiheterozygoteEarly adult4.71x10-6 
decreased body weight2 supporting datasetsDip2btm1a(EUCOMM)WtsiheterozygoteEarly adult2.21x10-8 
increased circulating calcium level1 supporting datasetDip2btm1a(EUCOMM)WtsiheterozygoteEarly adult1.21x10-5 
decreased mean corpuscular hemoglobin1 supporting datasetDip2btm1a(EUCOMM)WtsiheterozygoteEarly adult8.5x10-6 
increased blood urea nitrogen level1 supporting datasetDip2btm1a(EUCOMM)WtsiheterozygoteEarly adult5.01x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Dip2btm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Dip2btm1e(EUCOMM)WtsiTargeted, non-conditional allelees cell
Dip2btm47397(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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