Tedc1 | tubulin epsilon and delta complex 1
Physiological systems
20 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Integument Embryo Growth/size/body region Mortality/aging Cardiovascular system
12 No significant impact
4 Not tested
Data collections
Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal heart morphology | 1 supporting dataset | Tedc1em1(IMPC)Tcp | homozygote | E9.5 | N/A * | ||
| enlarged lymph nodes | 2 supporting datasets | Tedc1em1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Tedc1em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| abnormal uterus morphology | 1 supporting dataset | Tedc1em1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Tedc1em1(IMPC)Tcp | homozygote | E9.5 | N/A * | ||
| prenatal lethality prior to heart atrial septation | 1 supporting dataset | Tedc1em1(IMPC)Tcp | homozygote | E15.5 | N/A * | ||
| increased blood urea nitrogen level | 1 supporting dataset | Tedc1em1(IMPC)Tcp | heterozygote | Early adult | 5.61x10-5 | ||
| embryonic growth retardation | 1 supporting dataset | Tedc1em1(IMPC)Tcp | homozygote | E9.5 | N/A * | ||
| abnormal skin morphology | 2 supporting datasets | Tedc1em1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Tedc1em1(IMPC)Tcp | heterozygote | E9.5 | N/A * |
| | | | | | | | | | |
Human diseases caused by Tedc1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Tedc1.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Tedc1em1(IMPC)Tcp | Deletion | | mouse |
| Tedc1tm1(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Tedc1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Tedc1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |