Wsb2 | WD repeat and SOCS box-containing 2

Physiological systems

18 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Growth/size/body region Muscle Vision/eye Behavior/neurological Skeleton Cardiovascular system Craniofacial

9 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

0Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased locomotor activity	1 supporting dataset	Wsb2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.42x10^-5
decreased food intake	1 supporting dataset	Wsb2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.01x10^-9
decreased vertical activity	1 supporting dataset	Wsb2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.19x10^-8
decreased respiratory quotient	1 supporting dataset	Wsb2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.12x10^-10
female infertility	1 supporting dataset	Wsb2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased heart rate	1 supporting dataset	Wsb2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.01x10^-6
hyperactivity	2 supporting datasets	Wsb2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.58x10^-7
increased circulating alkaline phosphatase level	1 supporting dataset	Wsb2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.45x10^-8
abnormal tooth morphology	1 supporting dataset	Wsb2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.49x10^-12
abnormal retina blood vessel morphology	1 supporting dataset	Wsb2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.23x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Wsb2.

Associated images

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Histopathology

There is no histopathology data found for Wsb2.

IMPC related publications

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External links

No external links available for Wsb2.

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*Wsb2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Wsb2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Wsb2^{tm44148(L1L2_gt2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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