Xpo1 | exportin 1

GeneMGI:2144013Synonyms: Crm1

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Embryo Growth/size/body region Nervous system Cardiovascular system Mortality/aging

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased heart weight	1 supporting dataset	Xpo1^em1(IMPC)Mbp	heterozygote	Early adult	2.63x10^-12
hemorrhage	1 supporting dataset	Xpo1^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Xpo1^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Xpo1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
spina bifida	1 supporting dataset	Xpo1^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
prenatal lethality prior to heart atrial septation	1 supporting dataset	Xpo1^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Xpo1.

Associated images

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Histopathology

There is no histopathology data found for Xpo1.

IMPC related publications

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External links

No external links available for Xpo1.

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*Xpo1^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Xpo1^{tm1(NCOM)Cmhd}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell

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