Parp12 | poly (ADP-ribose) polymerase family, member 12

GeneMGI:2143990Synonyms: Zc3hdc1

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Respiratory system Hematopoietic system

15 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased pulmonary respiratory rate	1 supporting dataset	Parp12^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.1x10^-6
small testis	1 supporting dataset	Parp12^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Parp12^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
decreased pulmonary ventilation	2 supporting datasets	Parp12^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.89x10^-6
increased basophil cell number	1 supporting dataset	Parp12^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.99x10^-7
increased neutrophil cell number	1 supporting dataset	Parp12^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	8.06x10^-7
decreased bronchoconstrictive response	1 supporting dataset	Parp12^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.45x10^-9
increased mean platelet volume	1 supporting dataset	Parp12^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.85x10^-7
female infertility	1 supporting dataset	Parp12^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Parp12.

Associated images

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Histopathology

There is no histopathology data found for Parp12.

IMPC related publications

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External links

No external links available for Parp12.

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*Parp12^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Parp12^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Parp12^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Parp12^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Parp12^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Parp12^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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