Mbtd1 | mbt domain containing 1

GeneMGI:2143977Synonyms: hemp

Physiological systems

20 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Mortality/aging

18 No significant impact

4 Not tested

Data collections

Viability data
Body weight measurements
Embryo imaging data
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

increased lactate dehydrogenase level1 supporting datasetMbtd1tm2a(EUCOMM)WtsiheterozygoteEarly adult2.66x10-5 
preweaning lethality, incomplete penetrance1 supporting datasetMbtd1tm2a(EUCOMM)WtsihomozygoteEarly adultN/A * 
increased circulating LDL cholesterol level1 supporting datasetMbtd1tm2a(EUCOMM)WtsiheterozygoteEarly adult6.96x10-6 
increased circulating alanine transaminase level1 supporting datasetMbtd1tm2a(EUCOMM)WtsiheterozygoteEarly adult4.49x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Mbtd1tm2a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Mbtd1tm2e(EUCOMM)WtsiTargeted, non-conditional allelees cell
Mbtd1tm41585(L1L2_gt0)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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