Dot1l | DOT1 like histone lysine methyltransferase
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Vision/eye Mortality/aging Cardiovascular system
16 No significant impact
5 Not tested
Data collections
Viability data
Body weight measurements
Embryo imaging data
Body weight measurements
Embryo imaging data
Gene metrics:2Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal retina vasculature morphology | 1 supporting dataset | Dot1ltm1a(KOMP)Wtsi | heterozygote | Early adult | 5.45x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Dot1ltm1a(KOMP)Wtsi | homozygote | Early adult | N/A * |
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External links
No external links available for Dot1l.
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| Dot1ltm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dot1ltm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Dot1ltm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Dot1ltm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Dot1ltm3a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |