Zfp445 | zinc finger protein 445

GeneMGI:2143340Synonyms: ZNF168

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Hearing/vestibular/ear Vision/eye Nervous system Hematopoietic system Behavior/neurological Mortality/aging

12 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased red blood cell distribution width	1 supporting dataset	Zfp445^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.33x10^-8
increased circulating calcium level	1 supporting dataset	Zfp445^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.94x10^-7
decreased total retina thickness	1 supporting dataset	Zfp445^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2x10^-5
decreased total retina thickness	1 supporting dataset	Zfp445^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1x10^-4
abnormal brain morphology	1 supporting dataset	Zfp445^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased grip strength	2 supporting datasets	Zfp445^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.35x10^-6
preweaning lethality, incomplete penetrance	1 supporting dataset	Zfp445^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Zfp445.

Associated images

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Histopathology

There is no histopathology data found for Zfp445.

IMPC related publications

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External links

No external links available for Zfp445.

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*Zfp445^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Zfp445^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Zfp445^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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