Klhl18 | kelch-like 18

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Hematopoietic system Behavior/neurological

15 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased grip strength1 supporting datasetKlhl18tm1a(KOMP)WtsihomozygoteEarly adult1.07x10-5 
decreased hemoglobin content1 supporting datasetKlhl18tm1a(KOMP)WtsihomozygoteEarly adult2.51x10-7 
increased circulating magnesium level1 supporting datasetKlhl18tm1a(KOMP)WtsihomozygoteEarly adult2.48x10-7 
decreased erythrocyte cell number1 supporting datasetKlhl18tm1a(KOMP)WtsihomozygoteEarly adult7.61x10-8 
decreased hematocrit1 supporting datasetKlhl18tm1a(KOMP)WtsihomozygoteEarly adult1.33x10-8 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Klhl18tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Klhl18tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Klhl18tm42066(L1L2_Pgk_PM)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Klhl18tm42066(L1L2_gt2)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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