Phldb1 | pleckstrin homology like domain, family B, member 1

GeneMGI:2143230Synonyms: D330037A14Rik, LL5A

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Hematopoietic system Behavior/neurological Skeleton

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:6Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased grip strength2 supporting datasetsPhldb1em1(IMPC)JhomozygoteEarly adult2.31x10-9 
decreased bone mineral content2 supporting datasetsPhldb1em1(IMPC)JhomozygoteEarly adult2.3x10-7 
thrombocytopenia1 supporting datasetPhldb1em1(IMPC)JhomozygoteEarly adult2.28x10-5 
abnormal vocalization1 supporting datasetPhldb1em1(IMPC)JhomozygoteEarly adult1.73x10-5 
decreased bone mineral density1 supporting datasetPhldb1em1(IMPC)JhomozygoteEarly adult9.33x10-5 
decreased locomotor activity1 supporting datasetPhldb1em1(IMPC)JhomozygoteEarly adult1.08x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Phldb1em1(IMPC)JExon Deletionmouse
Phldb1tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell
Phldb1tm80555(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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