Edc3 | enhancer of mRNA decapping 3
Physiological systems
21 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Nervous system Vision/eye Hematopoietic system Renal/urinary system
11 No significant impact
3 Not tested
Data collections
Gene metrics:11Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal skin morphology | 2 supporting datasets | Edc3em1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| enlarged urinary bladder | 1 supporting dataset | Edc3em1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| single kidney | 1 supporting dataset | Edc3em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| enlarged kidney | 1 supporting dataset | Edc3em1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Edc3em1(IMPC)Tcp | heterozygote | Early adult | 1.2x10-5 | ||
| abnormal testis morphology | 1 supporting dataset | Edc3em1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| abnormal eye morphology | 1 supporting dataset | Edc3em1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| increased mean platelet volume | 1 supporting dataset | Edc3em1(IMPC)Tcp | homozygote | Early adult | 8.32x10-6 | ||
| decreased prepulse inhibition | 1 supporting dataset | Edc3em1(IMPC)Tcp | homozygote | Early adult | 3.93x10-5 | ||
| enlarged lymph nodes | 2 supporting datasets | Edc3em1(IMPC)Tcp | heterozygote | Early adult | N/A * |
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Human diseases caused by Edc3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Edc3.
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| Edc3em1(IMPC)Tcp | Exon Deletion | | mouse |
| Edc3tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Edc3tm78954(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |